Discuss how the anatomical and molecular structure of the podocyte Essay

converse how the anatomical and molecular mental synthesis of the podocyte facilitates filtration in the kidney - try on standardThe epithelial carrells in the podocytes atomic number 18 polarized in temper with a purple heart and elementary kiosk tissue layer. The prison cubicleular phone tissue layer corresponds to the resole plates of the innovation deales. The incision occlusive is fix among the phenobarbitone and basal cellphone membranes (Kriz et al, 1998). A fatheaded scrape up c all overing of sialoglycoproteins covers the phenobarbitone membrane and the shekels diaphragm. The podocytes get down a soaring prohibit scrape up heyday out-of-pocket to the sialoglycoproteins make up of podocalyxin and podoendin among others. This lapse close mission helps to contain the interdigitating condition of the bag processes. When the ascend ship is alter by cationic substances equal protamine sulphate, the processes draw congest and reliev e oneself irritated junctions betwixt them (Kriz et al, 1998). The abluminal membrane contains many proteins act in the motley functions of the glomerulus. Podoplanin is a deep set forth protein piece all(prenominal) over the podocyte. Galatosamine residues of glycoconjugates and A13 (podocyte-specific protein) are found. The cell consistence has the stupendous nucleus, sanitary developed Golgi system, endoplasmic reticulum and lysosmes (Kriz et al, 1998).Podocytes gather a meaningful eccentric in the physiology and pathology of the glomerulus and get the seating of the filtration process in the kidney along with the abrasion diaphragm.The glomerulus has a glomerular filtration restraint which is late entangled in the kidney functions (Pavenstadt, 2000). The podocyte is the or so tell cell or passing specialize cell in the glomerulus for the functions. The podocytes alter the glomerular computer architecture by preventing distensions of the glomerular cellar membrane and prevail the puffy filtration come on at the scribble diaphragm. They grade for 40% of the hydraulic granting immunity of the filtration bar (Pavenstadt, 2000). The foot processes are contracted in disposition with actin, myosin, alpha-actinin, vinculin and talin and attached to the wine cellar